International Scientific Surgical Association
The First International Scientific Teleconference
"new technologies in medicine - 2004"
S.V.Vasiliev
CEREBRAL FLOW IN PATIENTS WITH MODERATE ESSENTIAL HYPERTENSION
DEPENDING ON HYPERTENSION STROKES. INFLUENCE OF CAPTOPRIL AND CILAZAPRIL ON CEREBRAL FLOW
The regional cardiological clinic - center of diagnostics and cardiovascular surgery
Surgut, Russia
Purpose. To study the cerebral blood flow (CF) peculiarities in patients with moderate essential hypertension (MEH) by transcranial Doppler (TCD) before and after treatment with captopril and cilazapril within 30 days.
Methods. Administration of captopril and cilazapril studied in 60 patients with moderate essential hypertension. All of them were casually randomized in two groups of 30 people comparable by age, sex and duration of the disease. Cilazapril administrated by 2.5-5.0 mg in the morning time, captopril administrated by 12.5-25 mg three times per day. CF studied by TCD evaluating peak linear systolic vessel speed (LVS) before and after treatment in vessels: middle cerebral artery (MCA) in depths of 46, 50, 55, 60 mm; anterior and posterior cerebral arteries (ACA, PCA); internal carotid artery (ICA: siphon and neck segments); vertebral arteries in depths of 50, 60, 70 mm; sagittal sinus.
Results. High rates of LVS in right and left MCAs and left ACA discovered in patients with MEH in both groups of patients with hypertension strokes (HS).
Treatment by captopril within 30 days increased LVS of left MCA by 4.74% (p=0.046) in depth 60 mm, increased LVS of right MCA by 6.61% (p=0.03) in depth 46 mm, by 6,02% (р=0,02) in depth 50 mm. Usage of cilazapril decreased LVS of right MCA by 10.2% (р=0,04) in depth 46 mm. Its considered as a well-established fact that high LVS in a patient with arterial hypertension deteriorates CF and is a strong complicating factor of the disease.
Conclusion. Interpreting the data of TCD, patients suffering from MEH with HS had more high rates of LVS in both MCA and left ACA than ones without them. Captopril increased LVS of MCA on different depths of Doppler scanning whereas cilazapril decreased LVS in right MCA.
E-mail: bajuhin@okd.ru
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