International Scientific Surgical Association
The First International Scientific Teleconference
"new technologies in medicine - 2004"
P.K.Sodhi1, L.Verma2, R.M.Pandey3, S.K.Ratan4
EFFICACY OF 2% TOPICAL CYCLOSPORINE AS COMPARED TO 1.4% TOPICAL POLYVINYL ALCOHOL FOR TREATING DRY EYES OF NON-IMMUNE ORIGIN: A RANDOMISED CONTROL TRIAL
1Department of Ophthalmology, Safdarjung Hospital,
2New Delhi Centre For Sight,
3Department of Biostatistics, All India Institute of Medical Sciences,
4Department of Paediatric Surgery, Safdarjung Hospital,
New Delhi, India
Abstract. Background: The purpose of this study was to compare the efficacy of 2% topical cyclosporine (Cs) with 1.4% topical polyvinyl alcohol (PVA) for treatment of idiopathic dry eye syndrome.
Methods: Forty two patients (including 28 males and 24 females) in the age range of 18-85 years of dry eye were enrolled in the study. Appropriate history for ocular complaints, underlying systemic disease, predisposing environmental conditions and occupation of the patients was recorded. The baseline Schirmers test and tear film break up time was also recorded. The patients were randomly allocated into one of the two groups. Twenty six patients received 2 % topical Cs four times a day and twenty six patients received topical PVA four times a day. Follow up examination was done at two weeks for any side effects and at six months to assess the outcome of treatment.
Results: The mean age of the patients in Cs group was 52.618.1 years. The mean age of the subjects in PVA group was 46.911.3 years. With the use of topical Cs, there was a statistically significant relief in ocular complaints of foreign body sensation (p= 0.0067), itching (p= 0.03), conjunctival hyperemia (p= 0.02) and lacrimation (p= 0.001) while there was no statistically significant subjective relief in any of the ocular complaint with topical PVA. In the Cs group, the post treatment Schirmers test (8 mm; range 1-30mm) reading showed a statistically significant increase from its pre-treatment value (3mm; range 0-5mm) (p=0.004). In PVA group, the post treatment Schirmers test (3.61.07mm; range2-5 mm) reading did not show a statistically significant increase from its pre-treatment value (3.51.1mm; range2-5 mm) (p=0.59). In the Cs group, the post treatment tear film break up time (10.8 6.2 seconds) did not show a statistically significant increase from its pre-treatment value (10.2 5.4 seconds) (p= 0.78). Also, in the PVA group, the post treatment tear film break up time (10.3 1.7 seconds) did not show a statistically significant increase from its pre-treatment value (10.11.9 seconds) (p=0.16). Similar to PVA group, the patients in topical Cs group did not have any local or systemic side effect except for burning sensation in one patient and mild pain in another.
Interpretation: The efficacy of topical Cs (2%) is significantly more than topical PVA in treatment of dry eyes of non-immune origin.
Key words: Topical cyclosporine, dry eyes, Topical cyclosporine and adverse events.
Sodhi P.K., Verma L., Pandey R.M., Ratan S.K. EFFICACY OF 2% TOPICAL CYCLOSPORINE AS COMPARED TO 1.4% TOPICAL POLYVINYL ALCOHOL FOR TREATING DRY EYES OF NON-IMMUNE ORIGIN: A RANDOMISED CONTROL TRIAL // Новые технологии в медицине: Сб. докл. Первой международной дистанционной науч.-практ. конф., Санкт-Петербург, 15-30 марта 2004 г. СПб, 2004. С. 108-109
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