The First International Scientific Teleconference
"Cardiovascular Surgery and Angiology - 2003"
Yanushko A. V.
A NEW METHOD OF THE VEIN GRAFT TREATMENT USING MEROCYANINE-540
Center of Cardiology
Minsk, Belarus
.
The purpose of the research was a working out of a new method of the vein grafts treatment, which had in the basis a photodynamic inactivation of smooth muscle cells of a medial and an external membrane of a vein in Merocyanine-540 (Mc 540) presence.
The research had been conducted on 30 dogs samples of jugular and femoralis veins. The vessels were placed into a physiological solution, containing Mc 540 (10-4-10-7 M) and were exposed to the light of slide projector.
It has been determined optimum conditions of vein grafts irradiation and sensibilizator concentration necessary for choosing photooxidation of smooth muscle cells and adventitious fibroblasts without affecting the viability of endothelial cells.
The received data indicate the prospects of a new method of the treatment aimed at increasing in duration of vein grafts functioning in arterial positions.
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