International Scientific Surgical Association

The First International Scientific Teleconference

"new technologies in medicine - 2004"

S.V.Vasiliev

INFLUENCE OF CAPTOPRIL AND CILAZAPRIL ON MORNING RAISING OF BLOOD PRESSURE IN PATIENTS WITH MODERATE ESSENTIAL HYPERTENSION

The regional cardiological clinic - center of diagnostics and cardiovascular surgery

Surgut, Russia

Purpose. To study the influence of captopril and cilazapril on morning raising of systolic and diastolic blood pressure (MRBPs, MRBPd) in patients with essential moderate hypertension (MEH) by ambulatory blood pressure monitoring (ABPM).

 Methods. Administration of captopril and cilazapril studied in 60 patients with moderate essential hypertension. All of them were casually randomized in two groups of 30 people comparable by age, sex and duration of the disease. Cilazapril administrated by 2.5-5.0 mg in the morning time, captopril administrated by 12.5-25 mg three times per day. MRBP evaluated by ABPM before the drug administration and after finishing of 30-days treatment.

 Results. Influence of cilazapril and captopril on MRBP was different.

Captopril administration had no influence on MRBPs and MRBPd; moreover, there was a tendency to increasing MRBPs. Treatment by cilazapril decreased both MRBPs and MRBPd.

 Conclusion. In according with ABPM data, captopril had no influence on MRBP. Cilazapril once a day decreased MRBPs and MRBPd in patients with MEH.

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E-mail: bajuhin@okd.ru

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